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Filtered Search Results
Medchemexpress LLC Anti-Mouse Ly6G Anti 1mg | 1mg
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Anti-Mouse Ly6G Antibody (1A8) is a rat-derived anti-mouse Ly6G IgG2a type antibody inhibitor Anti-Mouse Ly6G Antibody (1A8) can deplete neutrophil in various mice Anti-Mouse Ly6G Antibody (1A8) can be used for the researches of inflammation such as arthritis and peritonitis[1][2]
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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BIOHIPPO HIF2a-sh-GFP/Luc
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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HIF2a-sh-GFP/Luc shRNA lentiviral vector expressing GFP/Luc with selection for studies in Human/Mouse Each vial provides a nominal titer of 2x10E6 transducing units TU Validated HIF2a shRNA Lentivirus High-titer shRNA lentiviral particles specific for human/mouse hypoxia-inducible factor 2 alpha (HIF2a/EPAS1) The shRNA has been validated to meet or exceed 70% HIF2a knockdown efficiency using a specific fluorescence-based method that is more rapid and reliable than qPCR The shRNA lentivirus is ultra-purified and concentrated to high-titer by PEG precipitation and sucrose gradient centrifugation and ideal for transducing difficult-to-transfect cells including thawed and/or primary cells Order a shRNA lentivirus set and receive lentivirus produced from mix of 2 independent shRNAs validated to knockdown the target gene ( 70%) plus control lentivirus produced from mix of 2 scrambled shRNA constructs
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Alamifovir | 193681-12-8 | 95.0% | 1 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Alamifovir is a purine nucleotide analogue prodrug with potent activity against wild-type and lamivudine-resistant hepatitis B virus (HBV). It is intended for research use in antiviral and in vitro pharmacology studies.
- Shows potent activity against HBV replication and sustained antiviral effect.
- Suitable for in vitro antiviral and resistance studies.
- Purity 95.0%.
- Molecular formula C19H20F6N5O5PS; molecular weight 575.42 g/mol.
- Supplied in small research quantities for assay work.
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Medchemexpress LLC TPN729MA 10mM 1mL | 1422955-52-9 | 632.73 g/mol | C29H40N6O8S | 1 ML
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TPN729MA (TPN729 maleate) is a selective phosphodiesterase type 5 (PDE5) inhibitor supplied for research use. It is provided as a maleate salt and is available as a 10 mM stock solution in DMSO (1 mL) and in multiple solid sizes.
- Selective phosphodiesterase type 5 (PDE5) inhibitor.
- Provided as a maleate salt for improved handling.
- Available as a 10 mM stock solution in DMSO, 1 mL.
- Also available in solid quantities (5 mg-100 mg).
- Molecular formula: C29H40N6O8S.
- Molecular weight: 632.73 g/mol.
- Purity: 99.5% (supplier stated).
- Storage: solid at 4°C; in solvent, -80°C up to 6 months or -20°C up to 1 month.
- CAS number: 1422955-52-9.
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Apexbio Technology LLC Darunavir Ethanolate 635728-49-3 10mM (in 1mL DMSO)
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Darunavir Ethanolate (CAS 635728-49-3) is a small-molecule inhibitor targeting HIV protease It is designed to inhibit HIV protease disrupting the proteolytic processing of viral polyproteins required for HIV replication Darunavir Ethanolate exerts its biological activity primarily through selective binding to the active site of HIV protease In cell-based studies it demonstrates inhibitory activity against both wild-type and protease inhibitor-resistant HIV strains with an IC50 value of 1 nM for wild-type HIV-1 protease Based on these pharmacological properties Darunavir Ethanolate holds research potential in studies of HIV/AIDS particularly for investigating antiviral resistance mechanisms and evaluating HIV replication inhibition in vitro
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BIOHIPPO PRE-TAL-BSD LV
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PRE-TAL-BSD is a transcription factor reporter lentiviral vector designed to monitor the target signaling pathway in living cells The construct carries a fluorescent reporter gene under the control of pathway responsive elements and includes a blasticidin selection marker to generate stable cell pools The lentivirus is provided as a ready to use VSV G pseudotyped preparation for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 5x10E6 transducing units TU Typical applications include pathway activation studies assay development compound screening and mechanism of action research The system is suitable for human and mouse cells and can be read using standard fluorescence microscopy flow cytometry or luciferase assays depending on the reporter gene This product is intended for research use only and is not for diagnostic or therapeutic procedures
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Apexbio Technology LLC GS-441524 1191237-69-0 25mg
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GS-441524 (CAS 1191237-69-0) is a nucleoside analog targeting viral RNA polymerase It functions by interfering with viral RNA polymerase activity thereby inhibiting viral RNA synthesis and replication GS-441524 exerts its biological activity primarily through inhibition of viral RNA synthesis In cell-based studies GS-441524 demonstrates inhibitory activity with an IC50 value of 0 78 M against feline infectious peritonitis virus Based on these pharmacological properties GS-441524 holds research potential in the treatment of feline infectious peritonitis (FIP)
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Cayman Chemical PAC1 Fatty Acids and Derivativ
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A procaspase-3 activator and a potential drug treatment in cancer cell lines with elevated levels of procaspase-3; exhibits an IC50 value of 3 nM for induction of cancer cell death without affecting non-cancerous cells
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Apexbio Technology LLC MMK 1 1mg
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MMK 1 (CAS 271246-66-3) is a highly selective agonist of formyl peptide receptor-like 1 (FPRL-1) exhibiting subnanomolar half-maximal effective concentration (EC50 2 nM) for FPRL-1 while showing minimal activity against FPR1 (EC50 10 000 nM) By engaging FPRL-1 MMK 1 induces chemotaxis and calcium mobilization in phagocytic leukocytes and enhances interleukin-1 (IL-1 ) production in human monocytes sensitive to pertussis toxin Its ability to modulate innate immune cell functions makes MMK 1 a valuable tool for investigating mechanisms of inflammation immune regulation and associated behavioral responses such as anxiety in preclinical research
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Medchemexpress LLC 25,26-dihydroxyvitamin D3 | 29261-12-9 | 95.5% | 416.64 g/mol | C27H44O3 | 10 MG
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25,26-Dihydroxyvitamin D3 is a research-grade metabolite of vitamin D3 used to study vitamin D metabolism and intestinal calcium transport. The compound is supplied as a white to off-white solid, with reported purity around 95.5%, and should be stored protected from light and under inert atmosphere for best stability.
- Metabolite of vitamin D3 with intestinal calcium transport activity.
- Applicable to studies of vitamin D metabolism and signaling.
- Reported purity 95.5%.
- Solid, white to off-white physical form.
- Storage: protect from light and store under inert atmosphere; in solvent, keep at -80°C for long-term.
- Intended for research use only.
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Apexbio Technology LLC AMD-070 558447-26-0 10mM (in 1mL DMSO)
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AMD-070 (CAS 558447-26-0) is a small-molecule antagonist targeting the chemokine receptor CXCR4 It is designed to inhibit CXCR4-mediated signaling thereby regulating cellular migration and CXCL12-induced MAPK pathway activation AMD-070 exerts its biological activity as an allosteric inhibitor of CXCR4 In cell-based studies AMD-070 demonstrates inhibition of tumor cell migration in melanoma cell models and suppresses X4-tropic HIV-1 replication by disrupting the gp120/CXCR4 interaction The compound exhibits an IC50 value of approximately 13 nM for CXCR4 and inhibits HIV-1 replication with IC50 values of 10 nM in human CXCR4-expressing HOS cells and 12 nM in CD4 CXCR4 T cells Based on these pharmacological properties AMD-070 holds research potential in cancer metastasis and HIV infection
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BIOHIPPO RUNX1-TAG-BSD LV
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RUNX1-TAG-BSD is a transcription factor reporter lentiviral vector designed to monitor the target signaling pathway in living cells The construct carries a fluorescent reporter gene under the control of pathway responsive elements and includes a blasticidin selection marker to generate stable cell pools The lentivirus is provided as a ready to use VSV G pseudotyped preparation for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 5x10E6 transducing units TU Typical applications include pathway activation studies assay development compound screening and mechanism of action research The system is suitable for human and mouse cells and can be read using standard fluorescence microscopy flow cytometry or luciferase assays depending on the reporter gene This product is intended for research use only and is not for diagnostic or therapeutic procedures
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Medchemexpress LLC Galicaftor | 1918143-53-9 | 98.56% | 559.46 | 50 MG
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Galicaftor is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. It can be used for cystic fibrosis research. In vitro, Galicaftor exhibits potent functional activity in primary patient cells harboring F508del/F508del CFTR, with an EC50 <10 nM. In rats, pharmacokinetic tests showed a T1/2 of 2.7 hours (i.v.) and bioavailability (%F) of 74% for intragastric administration.
- Potent and orally active cystic fibrosis transmembrane conductance regulator corrector
- Useful for cystic fibrosis research
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Medchemexpress LLC Lisaftoclax | 2180923-05-9 | 99.8% | 100 MG
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Lisaftoclax (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity. It exhibits IC50 values of 2 nM for Bcl-2 and 5.9 nM for Bcl-xl. In vitro, Lisaftoclax shows IC50 values of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4;11 cells and Bcl-xl dependent Molm13 cells.
- Dual Bcl-2 and Bcl-xl inhibitor.
- Demonstrates anti-tumor activity.
- High purity of 99.8%.
- Light yellow to yellow solid appearance.
- Consistent with structure by 1H NMR and MS.
- Stable as powder for 3 years at -20°C, 2 years at 4°C.
- Stable in solvent for 6 months at -80°C, 1 month at -20°C.
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Selleck Chemical LLC Sarsasapogenin S3607-5mg
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Sarsasapogenin (SAR Parigenin) is a steroidal sapogenin It can provoke the generation of reactive oxygen species and activate unfolded protein response (UPR) signaling pathways SAR potently inhibits NF- B and MAPK activation as well as IRAK1 TAK1 and I B phosphorylation in LPS-stimulated macrophages
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